Breaking all the Rules – Pushing the Boundaries of Lipinski’s Rule of 5

Lipinski’s Rule of 5 is a guideline in drug discovery that helps predict if a molecule is likely to be orally bioavailable. It’s a set of criteria based on molecular weight, hydrogen bond donors and acceptors, and lipophilicity that, when violated, suggest a compound might have poor absorption or permeation. However, new molecules emerging from discover often deviate from Lipinski’s Rule of 5. AustinPx’s amorphous dispersion technology, KinetiSol™ has enabled hundreds of violators of Lipinski’s Rule of 5, while offering other advantages over other methods like spray drying and hot-melt extrusion.